A thymidine triphosphate shape analog lacking Watson-Crick pairing ability is replicated with high sequence selectivity
نویسندگان
چکیده
منابع مشابه
Nucleobase pairing in expanded Watson-Crick-like genetic information systems.
To guide the design of alternative genetic systems, we measured melting temperatures of DNA duplexes containing matched and mismatched nucleobase pairs from natural and unnatural structures. The pairs were analyzed in terms of structural features, including nucleobase size, number of hydrogen bonds formed, the presence of uncompensated hydrogen bonding functional groups, the nature of the bond ...
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Tricyclo-DNA belongs to the family of conformationally restricted oligodeoxynucleotide analogues. It differs structurally from DNA by an additional ethylene bridge between the centers C(3') and C(5') of the nucleosides, to which a cyclopropane unit is fused for further enhancement of structural rigidity. The synthesis of the hitherto unknown tricyclodeoxynucleosides containing the bases cytosin...
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We present a base-pairing model of oligonucleotide duplex formation and show in detail its equivalence to the nearest-neighbor dimer methods from fits to free energy of duplex formation data for short DNA-DNA and DNA-RNA hybrids containing only Watson-Crick pairs. For completeness, the corresponding RNA-RNA parameters are included. In this approach, the connection between rank-deficient polymer...
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D0L systems constitute the simplest and most widely studied type of Lindenmayer systems. They have the remarkable property of generating their language as a (word) sequence and, consequently, are very suitable for modeling growth properties. In this paper a new type of D0L systems is introduced, where the parallelism presented in L systems is combined with the paradigm of (Watson-Crick) complem...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1997
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.94.20.10506